Aspartame has been proven safe through extensive study in animals and humans for more than two decades. The U.S. Food and Drug Administration (FDA) Commissioner, upon approving aspartame, noted, "Few compounds have withstood such detailed testing and repeated, close scrutiny, and the process through which aspartame has gone should provide the public with additional confidence of its safety." In addition to FDA, aspartame has been reviewed and determined to be safe by the Joint Expert Committee on Food Additives (JECFA) of the Food and Agriculture Organization/World Health Organization, the Scientific Committee on Food of the European Union, and the regulatory bodies of over 100 countries.

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